3-Dimensional Source Localization and
a LORETA Normative Database: Birth to 82 Years


  Launch LORETA.JPG (76844 bytes)      LORETA & NeuroGuide.JPG (66523 bytes)      LORETA ViewerV170.JPG (59147 bytes)      LORETA Viewer- ZScores.jpg (72051 bytes)      LORETA-Full&Hemispheres.jpg (59914 bytes)      LORETA Lobules & Brodmann.jpg (75959 bytes)


Once the Key Institute software (www.unizh.ch/keyinst/NewLORETA/Software/Software.htm) is installed on the users computer then the LORETA viewer program can be launched directly from the NeuroGuide edit window.  See the Key Institute documentation to learn how the cross-spectrum and *.crs file is computed.  

To review the Functional Location Literature click on the following links:


3-Dimensional LORETA Normative Database

                                                     LORETA Viewer- ZScores.jpg (72051 bytes)        Rt. Hem-Hematoma.jpg (64316 bytes)       Epilepsy-fig.3.jpg (59950 bytes)       Rt. Frontal-Stroke.jpg (63576 bytes)


The LORETA normative database used the Key Institute's 'T' matrix and cross-spectrum equations to compute the cross-spectrum of the EEG from each subject in the NeuroGuide normative database (click here for a description of the selection criteria and age range, etc.) for each 2,394 gray matter pixel.  The NeuroGuide software was tested by comparisons to the Key Institute software programs.   After log10 transforms of the Key Institute current density values, the means and standard deviations of the 2,394 LORETA currents were computed for different age groups from birth to 82 years thus enabling a Z score to be computed for each of the 2,394 gray matter pixels and displayed using the LORETA viewer and the Key Institute cross-spectral equations.   For further detail see how tests of Gaussian distributions and cross-validations were computed.

Time domain export is also available using NeuroGuide so that individual EEG events can be examined in detail in the time domain as well as to compare source localization in the frequency domain.

Export the digital time series to the Key Institute's LORETA EEG Cross-Spectra program and verify the equivalence of the Key Institute LORETA Explorer for EEG Cross-Spectra to the same data computed by NeuroGuide.


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